Aminoleban Injection Specification
Requires Prescription (YES/NO)
Yes
Generics
Aminoacetic acid 9g, L-alanine 7.5g, L-arginine HCl 7.3g, L-arginine 6g, L-cysteine HCl monohydrate 0.4g, L-cysteine 0.3g, L-histidine HCl monohydrate 3.2g, L-histidine 2.4g, L-isoleucine 9g, L-leucine 11g, L-Lysine HCl 7.6g, L-lysine 6.1 g, L-methionine 1g, L-phenylalanine 1g, L-proline 8g, L-serine 5g, L-threonine 4.5g, L-tryptophan 0.7g, L-valine 8.4g
Used For
Liver Disorder
How it works
AMINOLEBAN normalized the pattern of free amino acids in the plasma and brain, improved serotonin metabolism in the brain and corrected a sleep-wakefulness pattern in a rat model of chronic hepatic insufficiency which underwent a portacaval shunt operation. 2. When infused to portacaval-shunted rats loaded with ammonia, AMINOLEBAN improved EEG pattern and corrected amine metabolism in the brain as evidenced by correction of the free amino acid pattern in the plasma and brain and by suppression of an increase of the false neurotransmitter octopamine.
Aminoleban Injection Usage And Safety
Dosage
Aminoacetic acid 9g, L-alanine 7.5g, L-arginine HCl 7.3g, L-arginine 6g, L-cysteine HCl monohydrate 0.4g, L-cysteine 0.3g, L-histidine HCl monohydrate 3.2g, L-histidine 2.4g, L-isoleucine 9g, L-leucine 11g, L-Lysine HCl 7.6g, L-lysine 6.1 g, L-methionine 1g, L-phenylalanine 1g, L-proline 8g, L-serine 5g, L-threonine 4.5g, L-tryptophan 0.7g, L-valine 8.4g
Side Effects
1) Clinically significant adverse reactions: (1) Hypoglycemia: Hypoglycemia may occur. If the patient develops hypoglycemia, glucose should be administered promptly by intravenous infusion. In addition, appropriate nutrition management is required in such patients. (2) Hyperammonemia: Hyperammonemia has been reported. If the patient develops persistent hyperammonemia during the administration of AMINOLEBAN®,discontinue administration and take measures to eliminate other nitrogen sources.2) Other adverse reactions : (1) Hypersensitivity : Symptoms such as skin rash may occur rarely. In the event of skin rash, discontinue the administration and institute appropriate treatment. (2) Gastrointestinal : Symptoms such as nausea and vomiting may occur infrequently. (3) Cardiovascular : Symptoms such as chest discomfort and palpitation may occur infrequently. (4) Metabolic : The nitrogen content of this preparation may induce a transient increase in blood ammonia concentrations. (5) Large dose and rapid administration : Acidosis may occur when large doses are administered rapidly.(6) Others : Chills, fever, headache and vascular pain may infrequently occur.
Drug Interactions
Some medicines and this medicine may interfere with each other. Your doctor or pharmacist may have more information on medicines to be careful with or to avoid while using this medicine .
Indication
Treatment of hepatic encephalopathy in patients with chronic liver disease.
When not to Use
It is contraindicated in the following patients : (1) Patients with serious renal disorder (patients on dialysis or hemofiltration are excluded) [Urea and other amino acid metabolites may be retained, which mayworsen the patient’s clinical condition.](2) Patients with abnormal amino acid metabolism (Since the infused amino acids are not adequately metabolized, the patient’s clinical condition may be worsened.)
Aminoleban Injection Precautions
Precaution
The volume of urea, etc. removed and accumulated in patients on dialysis or hemofiltration with serious renal disorder varies depending on the dialysis method and patients’ conditions. Initiation and continuation of administration should be determined after the patient’s conditions are carefully checked based on assessment of blood biochemistry, acid-base equilibrium, and body-fluid balance, etc .
Aminoleban Injection Warnings
Warning 1
AMINOLEBAN Infusion should be administered with caution in Patients with severe acidosis (The patient’s clinical condition may be worsened.)
Warning 2
AMINOLEBAN Infusion should be administered with caution in Patients with congestive cardiac failure (An increase in the circulating blood volume may worsen the patient’s clinical condition.)
Warning 3
AMINOLEBAN Infusion should be administered with caution Patients on dialysis or hemofiltration with serious renal disorder .
Aminoleban Injection Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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