Clenil Commpositum 50+100 Inh

Name: Clenil Commpositum 50+100 Inh
Brand: CHIESI PHARMACEUTICALS
Price: 356.53

Brand : chiesi pharmaceuticals

Rs. 356.53

Rs. 375.29

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Clenil Commpositum Specification

Requires Prescription (YES/NO)

Yes

Generics

Beclomethasone Dipropionate , Salbutamol

Used For

Asthma

How it works

Salbutamol: Salbutamol is a selective ß2-adrenoceptor agonist. At therapeutic doses it acts on the ß2-adrenoceptors of bronchial muscle providing short acting (4-6 hours) bronchodilation with a fast onset (within 5 minutes) in reversible airways obstruction. Beclomethasone dipropionate: Beclomethasone dipropionate is a pro-drug with weak glucocorticoid receptor binding affinity. It is extensively hydrolysed via esterase enzymes to the active metabolite beclomethasone-17-monopropionate (B-17-MP), which has potent topical anti-inflammatory activity .

Clenil Commpositum Usage And Safety

Dosage

Beclomethasone Dipropionate , Salbutamol

Side Effects

Salbutamol: Tremor, headache, tachycardia, palpitations, mouth and throat irritation, muscle cramps, hypokalemia, peripheral vasodilatation, hypersensitivity reactions including angioedema, urticaria, bronchospasm, hypotension and collapse, hyperactivity, cardiac arrhythmias (including atrial fibrillation, supraventricular tachycardia and extrasystoles), paradoxical bronchospasm, myocardial ischemia.Beclomethasone dipropionate: Adrenal suppression, growth retardation in children and adolescents, decrease in bone mineral density, cataract, glaucoma, paradoxical bronchospasm with an immediate increase in wheezing, shortness of breath and cough after dosing, hypersensitivity reactions including rashes, urticaria, pruritus, erythema, oedema of the eyes, face, lips and throat, candidiasis of the mouth and throat, hoarseness or throat irritation, psychiatric disorders including psychomotor hyperactivity, sleep disorders, anxiety, depression, aggression and behavioural changes (predominantly in children).

Drug Interactions

Monoamine oxidase inhibitors, tricyclic antidepressants , beta-blockers , corticosteroids, diuretics or xanthines , CYP 3A4 inhibitors (e.g. ketoconazole, itraconazole, nelfinavir, ritonavir).

Indication

Salbutamol+Beclome thasone dipropionate is indicated for the long term management of asthma only when the need for inhaled corticosteroid and bronchodilator therapy has been established.

When not to Use

Salbutamol+Beclomethasone dipropionate is contraindicated in patients with hypersensitivity to the drug or any component of the product. - Inhaled salbutamol is not appropriate for managing premature labour; therefore salbutamol inhaler should not be used for threatened abortion.

Clenil Commpositum Precautions

Precaution

Patient's inhaler technique should be checked to make sure that inhaler actuation is synchronised with inspiration of breath for optimum delivery of drug to the lungs.

Clenil Commpositum Warnings

Warning 1

In the event of a previously effective dose of inhaled salbutamol failing to give relief for at least three hours, the patient should be advised to seek medical advice in order that any necessary additional steps may be taken.

Warning 2

Cardiovascular effects may be seen with sympathomimetic drugs, including salbutamol. Patients with underlying severe heart disease (e.g., ischemic heart disease, arrhythmia or severe heart failure) whoare receiving salbutamol should be warned to seek medical advice if they experience chest pain or other symptoms of worsening heart disease.

Warning 3

Increasing use of short-acting inhaled ß2-agonists to control symptoms indicates deterioration of asthma control. Consideration should be given to starting or increasing corticosteroid therapy.