Covam Plus Tablets 10Mg+160Mg+12.5Mg (1 Box = 4 Strips) (1 Strip = 7 Tablets)
Brand : getz pharma pakistan
Rs. 554.12
Rs. 583.24
|
QUICK DELIVERY
Covam Plus Specification
Requires Prescription (YES/NO)
Yes
Generics
Valsartan, Amlodipine and Hydrochlorothiazide
Used For
Hypertension
How it works
Valsartan : Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Amlodipine is a dihydropyridine calcium channel blocker Amlodipine binds to both dihydropyridine and non-dihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Hydrochlorothiazide : The mode of action of thiazides is through inhibition of the Na+Cl- symporter perhaps by competing for the Cl- site, thereby affecting the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts and indirectly, reducing plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium.
Covam Plus Usage And Safety
Dosage
Valsartan, Amlodipine and Hydrochlorothiazide
Side Effects
Agranulocytosis, bone marrow failure , Hemoglobin and Hematocrit decreased , Hemolytic anemia , Leukopenia, Neutropenia , Thrombocytopenia sometimes with purpura , Aplastic anemia , Anorexia , Hypercalcaemia , Hyperglycemia , Hyperlipidemia , Hyperuricaemia , Hypochloraemic alkalosis , Hypokalemia , Hypomagnesaemia , Headache , Hypertonia , Visual disturbance , Arrhythmias (including bradycardia, ventricular tachycardia, and atrial fibrillation).
Drug Interactions
Amlodipine : CYP3A4 inhibitors (protease inhibitors: ritonavir, azole antifungals: ketoconazole or itraconazole, macrolides: erythromycin or clarithromycin, verapamil or diltiazem) , CYP3A4 inducers (e.g. anticonvulsants: carbamazepine, phenobarbital, phenytoin, fosphenytoin, primidone; rifampicin and Hypericum perforatum ) , Sildenafil , Simvastatin , Immunosuppressants , Dantrolene infusion , Grape fruit. Valsartan : Potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride) , heparin , NSAIDs, including selective COX-2 inhibitors , rifampicin, ciclosporin , ritonavir , Lithium . Hydrochlorothiazide Metformin , antidepressants, antipsychotics, antiepileptics such as carbamazepine , cholestyramine or colestipol , Cyclosporine , Lithium , Alcohol, barbiturates or narcotics , Amantadine , Beta blockers and diazoxide , Cytotoxic agents , Digitalis glycosides , Iodine contrasting agents , Methyldopa , tubocurarine.
Indication
It (Valsartan, Amlodipine and Hydrochlorothiazide) is indicated for the treatment of essential hypertension in adults.
When not to Use
• Hypersensitivity condition to valsartan, amlodipine, hydrochlorothiazide or other sulphonamide or dihydropyridine derivatives.• Second and third trimesters of pregnancy• Severe hepatic impairment, biliary cirrhosis or cholestasis.
Covam Plus Precautions
Precaution
It should be used with caution in patients with unilateral or bilateral renal artery stenosis or stenosis to a solitary kidney since blood urea and serum creatinine may increase in such patients.
Covam Plus Warnings
Warning 1
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations.
Warning 2
In patients with an activated renin-angiotensin system, such as volume and/or salt-depleted patients receiving high doses of diuretics, symptomatic hypotension may occur. This condition should be corrected prior to administration of Valsartan/amlodipine/HCT, or the treatment should start under close medical supervision.
Warning 3
Changes in renal function including acute renal failure can be caused by drugs that inhibit the renin-angiotensin system and by diuretics.
Covam Plus Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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Rs. 370.50
Rs. 390.00
treatan tablets 16mg (1 box = 2 strips) (1 strip = 14 tablets)
Rs. 898.80
Rs. 946.20
baritec tablets 40mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 380.00
Rs. 400.00
baritec tablets 20mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 266.00
Rs. 280.00
ramipace tablets 5mg (1 strip = 14 tablets)
Rs. 346.64
Rs. 364.84
zestril tablets 20mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 710.50
Rs. 747.88
zestril tablets 10mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 425.60
Rs. 448.00
monitor tablets 5mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 209.02
Rs. 220.00
merol tablets 25mg (1 strip = 10 tablets)
Rs. 34.20
Rs. 36.03
tritace tablets 10mg (1 strip = 14 tablets)
Rs. 635.18
Rs. 668.57
merol tablets 50mg (1 strip = 10 tablets)
Rs. 66.50
Rs. 70.00
inderal tablets 40mg (1 bottle = 50 tablets)
Rs. 259.00
Rs. 272.86
valam tablets 5mg/80mg (1 strip = 7 tablets)
Rs. 214.41
Rs. 225.68
inderal tablets 10mg (1 bottle = 50 tablets)
Rs. 134.50
Rs. 141.50
valtec tablets 80mg (1 strip = 14 tablets)
Rs. 240.38
Rs. 253.00
valtec tablets 40mg (1 strip = 14 tablets)
Rs. 153.02
Rs. 161.00
avsar tablets 5/80mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 374.36
Rs. 394.00
cabok tablets 5mg (1 strip = 10 tablets)
Rs. 112.80
Rs. 118.75
onato tablets 5mg (1 strip = 10 tablets)
Rs. 80.80
Rs. 85.00
treatan tablets 8mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 330.26
Rs. 347.71
treatan tablets 4mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 270.76
Rs. 285.00
tansin tablets 50mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 218.00
Rs. 229.44
nebil tablets 2.5mg (1 strip = 7 tablets)
Rs. 106.89
Rs. 112.50
advant tablets 8mg (1 strip = 7 tablets)
Rs. 218.47
Rs. 230.00
advant tablets 16mg (1 strip = 7 tablets)
Rs. 287.35
Rs. 302.50
sofvasc tablets 10mg (1 box = 2 strips) (1 strip = 15 tablets)
Rs. 663.00
Rs. 697.99
corace tablets 5mg (1 strip = 10 tablets)
Rs. 74.00
Rs. 77.92
zestril tablets 5mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 226.10
Rs. 238.00
sartan tablets 50mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 332.50
Rs. 350.00
irecon tablets 75mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 190.00
Rs. 200.00
olesta tablets 20mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 264.40
Rs. 278.28
co-renitec tablets 10mg/25mg (1 strip = 10 tablets)
Rs. 235.30
Rs. 247.67
telsan tablets 80mg (1 strip = 7 tablets)
Rs. 330.33
Rs. 347.70
telsan tablets 40mg (1 strip = 7 tablets)
Rs. 222.04
Rs. 233.70
telsan tablets 20mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 247.00
Rs. 260.00
vedicar tablets 25mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 266.00
Rs. 280.00
omsana tablets 40mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 726.74
Rs. 765.00
byscard tablets 5mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 292.60
Rs. 308.00
byscard tablets 10mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 420.00
Rs. 442.04
tritace tablets 5mg (1 box = 2 strips) (1 strip = 14 tablets)
Rs. 1,149.12
Rs. 1,209.60
lame tablets 10mg (1 strip = 15 tablets)
Rs. 230.40
Rs. 242.50
calan tablets 80mg (1 bottle = 50 tablets)
Rs. 235.50
Rs. 247.64
tasmi tablets 20mg (1 strip = 7 tablets)
Rs. 136.99
Rs. 144.18
actim tablets 10mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 259.42
Rs. 273.03
tasmi tablets 40mg (1 strip = 7 tablets)
Rs. 210.42
Rs. 221.48
advantec tablets 16mg+12.5mg (1 strip = 14 tablets)
Rs. 498.82
Rs. 525.00
xavor tablets 50mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 254.50
Rs. 267.90
lame tablets 5mg (1 strip = 15 tablets)
Rs. 118.80
Rs. 125.00
sofvasc tablets 5mg (1 strip = 15 tablets)
Rs. 169.50
Rs. 178.43
treatan-d tablets 16mg/12.5mg (1 strip = 14 tablets)
Rs. 439.74
Rs. 462.85
actim tablets 5mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 156.52
Rs. 164.80
nebil tablets 5mg (1 strip = 7 tablets)
Rs. 180.53
Rs. 190.00
olesta-am tablets 10mg/20mg (1 strip = 10 tablets)
Rs. 277.90
Rs. 292.50
metxone tablets 5mg (1 box = 10 tablets)
Rs. 438.90
Rs. 462.00
bisoprolol fumarate tablets 10mg
Rs. 12.05
Rs. 12.69
bisoprolol tablets 5mg (1 box = 14 tablets)
Rs. 121.10
Rs. 127.54
triforge tablets 10/320/25mg (1 strip = 7 tablets)
Rs. 99.75
Rs. 105.00
amodip tablets 5mg (1 box = 3 strips) (1 strip = 10 tablets)
Rs. 338.10
Rs. 356.00
nabiz tablets 10mg (1 box = 14 tablets)
Rs. 408.38
Rs. 429.94
nabiz tablets 5mg (1 box = 14 tablets)
Rs. 273.84
Rs. 288.24
nabiz tablets 2.5mg (1 box = 14 tablets)
Rs. 163.24
Rs. 171.76
av-sartan tablets 5mg/160mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 503.44
Rs. 530.00
nibovo tablets 10mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 385.40
Rs. 405.69
nifedil tablets 30mg (1 bottle = 30 tablets)
Rs. 247.00
Rs. 260.00
nebivol tablets 5mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 226.10
Rs. 238.00
corbis tablets 2.5mg (1 box = 2 strips) (1 strip = 10 tablets)
Rs. 85.60
Rs. 90.00
valtec amh tablets 10/160/12.5mg (1 box = 2 strips) (1 strip = 14 tablets)
Rs. 368.48
Rs. 388.00
telmis tablets 20mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 190.00
Rs. 200.00
exval-a tablets 10mg/160mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 456.12
Rs. 480.06
exval-a tablets 5mg/160mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 389.62
Rs. 410.06
baritec-a tablets 5mg/40mg (1 box = 2 strips) (1 strip = 10 tablets)
Rs. 731.60
Rs. 770.00
telmis tablets 40mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 359.10
Rs. 378.00
triplixam tablets 5mg/1.25mg (1 bottle = 30 tablets)
Rs. 1,083.00
Rs. 1,140.00
exval-a tablets 5mg/80mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 308.70
Rs. 325.00
covance tablets 10mg/160mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 684.04
Rs. 720.01
nebicare tablets 5mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 250.74
Rs. 263.93
nebicare tablets 2.5mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 152.04
Rs. 160.02
covance tablets 5mg/160mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 484.54
Rs. 510.00
valid tablets 80mg (1 box = 2 strips) (1 strip = 14 tablets)
Rs. 504.56
Rs. 531.00
byvas tablets 2.5mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 184.94
Rs. 194.73
byvas tablets 5mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 332.50
Rs. 350.00
valtec amh tablets 5/160/12.5mg (1 box = 2 strips) (1 strip = 14 tablets)
Rs. 342.16
Rs. 360.08
nibovo tablets 2.5mg (1 box = 3 strips) (1 strip = 10 tablets)
Rs. 455.70
Rs. 479.70
amodip-v tablets 5mg/80mg (1 box = 2 strips) (1 strip = 7 tablets)
Rs. 335.58
Rs. 353.30
diasar tablets 5mg/80mg (1 strip = 7 tablets)
Rs. 163.38
Rs. 172.00
av-sartan tablets 10mg/160mg (1 strip = 7 tablets)
Rs. 284.97
Rs. 300.00
nibovo tablets 5mg (1 strip = 10 tablets)
Rs. 246.90
Rs. 259.90
telmis-a tablets 80mg+5mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 478.80
Rs. 504.00
amper tablets 5mg/4mg (1 box = 1 strip)(1 strip = 10 tablets)
Rs. 313.50
Rs. 330.00
baritec-a tablets 20mg+5mg (1 strip = 10 tablets)
Rs. 256.50
Rs. 270.00
av-sartan tablets 5mg + 80mg (1 strip = 7 tablets)
Rs. 180.53
Rs. 190.00
amstan tablets 5mg+80mg (1 box = 2 strips) (1 strip = 14 tablets)
Rs. 771.40
Rs. 812.00
ramipace tablets 2.5mg (1 strip = 14 tablets)
Rs. 270.76
Rs. 285.00
probase tablets 5mg (1 strip = 10 tablets)
Rs. 114.00
Rs. 120.00
cardiosil tablets 5mg (1 strip = 10 tablets)
Rs. 113.00
Rs. 118.90
leradip tablets 10mg (1 box = 1 strip)(1 strip = 14 tablets)
Rs. 730.52
Rs. 769.00
neopres tablets 5mg (1 strip = 10 tablets)
Rs. 48.60
Rs. 51.18
valtec-am tablets 5mg/160mg (1 strip = 14 tablets)
Rs. 372.40
Rs. 392.00
valtec-am tablets 10mg/160mg (1 strip = 14 tablets)
Rs. 399.00
Rs. 420.00
valtec-am tablets 5mg/80mg (1 strip = 14 tablets)
Rs. 282.66
Rs. 297.50
qsartan plus tablets 50/12.5mg (1 strip = 10 tablets)
Rs. 211.10
Rs. 222.19
qsartan tablets 50mg (1 strip = 10 tablets)
Rs. 174.80
Rs. 184.00
qsartan tablets 25mg (1 strip = 10 tablets)
Rs. 143.90
Rs. 151.50
valsar-m tablets 10mg+160mg (1 strip = 7 tablets)
Rs. 308.77
Rs. 325.00
valsar-m tablets 5mg+160mg (1 strip = 7 tablets)
Rs. 266.00
Rs. 280.00
valsar-m tablets 5mg+80mg (1 strip = 7 tablets)
Rs. 206.15
Rs. 217.00
amlo-q tablets 5mg (1 strip = 10 tablets)
Rs. 102.60
Rs. 108.00
amlo-q tablets 10mg (1 strip = 10 tablets)
Rs. 122.80
Rs. 129.28
arbi-d tablets 300mg/25mg (1 strip = 7 tablets)
Rs. 394.38
Rs. 415.10