Exelon 4.6Mg Patch 5 30S

Name: Exelon 4.6Mg Patch 5 30S
Brand: NOVARTIS PHARMACEUTICALS
Price: 19910.10

Brand : novartis pharmaceuticals

Rs. 19,910.10

Rs. 20,957.90

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Exelon 4.6Mg Specification

Requires Prescription (YES/NO)

Yes

Generics

Rivastigmine

Used For

Alzheimer

How it works

Pathological changes in dementia such as Alzheimer’s Disease involve cholinergic neuronal pathways that project from the basal forebrain to the cerebral cortex and hippocampus. These pathways are known to be involved in attention, learning and memory and other cognitive processes. Rivastigmine, a brain-selective acetyl- and butyryl-cholinesterase inhibitor of the carbamate type, is thought to facilitate cholinergic neurotransmission by slowing the degradation of acetylcholine released by functionally intact cholinergic neurons. Data from animal studies indicate that rivastigmine selectively increases the availability of acetylcholine in the cortex and hippocampus. Thus, Exelon may have an ameliorative effect on cholinergicmediated cognitive deficits associated with Alzheimer’s Disease and with Parkinson’s disease. In addition, there is some evidence that cholinesterase inhibition could slow the formation of amyloidogenic beta-amyloid-precursor protein (APP) fragments, and thus of amyloid plaques, which are one of the main pathological features of Alzheimer’s Disease.

Exelon 4.6Mg Usage And Safety

Dosage

Rivastigmine

Side Effects

Blood and Lymphatic System Disorders: Frequent: Anemia ; Cardiac Disorders: Infrequent: Angina pectoris, cardiac failure, bradycardia, atrial fibrillation, supraventricular extrasystoles, myocardial infarction, tachycardia, arrhythmia, atrioventricular block ; Ear and Labyrinth Disorders: Infrequent: Tinnitus. Eye Disorders: Infrequent: Cataract, glaucoma, vision blurred ; Gastrointestinal System: Frequent: Constipation, gastritis. Infrequent: Gastroesophageal reflux disease, hematochezia, peptic ulcer, hematemesis, pancreatitis, salivary hypersecretion ; General Disorders and Administration Site Conditions: Infrequent: Application site dermatitis, application site irritation, peripheral edema, chest pain, application site eczema, hyperpyrexia ; Hepatobiliary Disorders: Infrequent: Cholecystitis. Infections and Infestations: Frequent: Nasopharyngitis, pneumonia. Infrequent: Diverticulitis ; Injury, Poisoning and Procedural Complications: Frequent: Fall. Infrequent: Hip fracture, subdural hematoma .

Drug Interactions

Rivastigmine transdermal system should not be given together with other medicines with similar effects (cholinomimetic agents) or with anticholinergic medicines.

Indication

Rivastigmine transdermal system contains rivastigimine, an acetylcholinesterase inhibitor indicated for the: - Treatment of mild to moderate dementia of the Alzheimer’s type - Treatment of mild to moderate dementia associated with Parkinson’s disease

When not to Use

Rivastigmine transdermal system is contraindicated in patients with known hypersensitivity to rivastigmine, other carbamate derivatives, or other components of the formulation .

Exelon 4.6Mg Precautions

Precaution

At higher than recommended doses caregivers should be advised of the high incidence of nausea and vomiting associated with the use of this Patch along with the possibility of anorexia and weight loss. Caregivers should be encouraged to monitor for these adverse events and inform the physician if they occur .

Exelon 4.6Mg Warnings

Warning 1

Rivastigmine , as a cholinesterase inhibitor, is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia.

Warning 2

Like other drugs that increase cholinergic activity, Rivastigmine transdermal system should be used with care in patients with a history of asthma or obstructive pulmonary disease.

Warning 3

Patients or caregivers should be instructed to fold the patch in half after use and to discard it out of the reach and sight of children and pets. They should also be informed that drug still remains in the patch after 24-hour usage. They should be instructed to avoid eye contact and to wash their hands after handling the patch .