Pyodine Solution Specification
Requires Prescription (YES/NO)
Yes
Generics
Glycopyrrolate USP
Used For
Anti-Muscaranic
How it works
The following pharmacological effects are observed: Pyrolate (Glycopyrrolate Injection USP) inhibits the muscarinic actions of acetyl choline. Depending on the dose, Pyrolate (Glycopyrrolate Injection USP) may reduce the motility and secretory activity of the gastrointestinal system, the tone of the ureter and urinary bladder. It also has a slight relaxant action on the bile duct and gallbladder. In general, smaller doses of anti-cholinergics inhibit salivary and bronchial secretions, sweating and can cause dilatation of the pupil and increase in heart rate. Large doses are required to decrease motility of the gastrointestinal and urinary tracts and to inhibit the gastric acid secretion. Anti-spasmodic effect on gastrointestinal tract is due to the direct action on smooth muscle .
Pyodine Solution Usage And Safety
Dosage
Glycopyrrolate USP
Side Effects
Anti-cholinergics produce certain side effects most of which are extension of their pharmacological actions; they include: dry mouth, urinary retention, blurred vision, tachycardia, decreased sweating, loss of taste, headache, drowsiness, weakness, nausea, vomiting, suppression of lactation, constipation, allergic reactions and some degree of mental confusion or excitement.
Drug Interactions
Amantadine , cyclopropane , anticholinergic agents , levodopa .
Indication
INDICATIONS: a) Anti-Muscarinic l Pyrolate (Glycopyrrolate Injection USP) is indicated for use as a pre-operative, anti-muscarinic drug to reduce salivary, tracheo-bronchial, and pharyngeal secretions. l To reduce the volume of free gastric acid and to raise pH of gastric contents above 2.5. l It also blocks cardiac vagal inhibitory reflexes during induction and intubation. b) Anti -Arrhythmic Pyrolate (Glycopyrrolate Injection USP) may be used intra-operatively to counteract drug induced or vagal traction reflexes with associated arrhythmias. c) Reversal of Neuromuscular Blockade Pyrolate (Glycopyrrolate Injection USP) is indicated to reverse the neuromuscular block produced by non-depolarizing neuromuscular blocking agents, in combination with Neo-choline (Neostigmine) and pyridostigmine.
When not to Use
Known hypersensitivity to glycopyrrolate . Due to its benzyl alcohol content, Pyrolate should not be used in newborn or children less than 1 month of age. . Concurrent glaucoma. . Obstructive diseases of the gastrointestinal tract (as in achalasia, pyloroduodenal stenosis) . Paralytic ileus, intestinal atony. Un-stable cardiovascular status in acute haemorrhage. Severe ulcerative colitis. Myasthenia gravis.
Pyodine Solution Precautions
Precaution
Investigate any tachycardia since an increase in heart rate may occur .
Pyodine Solution Warnings
Warning 1
Use with caution in patients with coronary artery disease, congestive heart failure, hypertension and hyperthyroidism .
Warning 2
Due to its benzyl alcohol content, Pyrolate should not be used in newborn or children less than 1 month of age.
Warning 3
Un-stable cardiovascular status in acute haemorrhage .
Pyodine Solution Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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