Xatral-Sr Tablets 5Mg (1 Strip = 14 Tablets)

Name: Xatral-Sr Tablets 5Mg (1 Strip = 14 Tablets)
Brand: SANOFI-AVENTIS PAKISTAN LTD.
Price: 732.62

Brand : sanofi-aventis pakistan ltd.

Rs. 732.62

Rs. 771.20

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Xatral-Sr Tablets Specification

Requires Prescription (YES/NO)

Yes

Generics

Alfuzosin

Used For

Benign Prostatic Hyperplasia

How it works

The symptoms associated with benign prostatic hyperplasia (BPH) such as urinary frequency, nocturia, weak stream, hesitancy and incomplete emptying are related to two components, anatomical (static) and functional (dynamic). The static component is related to the prostate size. Prostate size alone does not correlate with symptom severity. The dynamic component is a function of the smooth muscle tone in the prostate and its capsule, the bladder neck, and the bladder base as well as the prostatic urethra. The smooth muscle tone is regulated by alphaadrenergic receptors. Alfuzosin exhibits selectivity for alpha1-adrenergic receptors in the lower urinary tract. Blockade of these adrenoreceptors can cause smooth muscle in the bladder neck and prostate to relax, resulting in an improvement in urine flow and a reduction in symptoms of BPH. Alfuzosin HCl extended-release is a selective antagonist of post-synaptic alpha1-adrenoreceptors, which are located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra.

Xatral-Sr Tablets Usage And Safety

Dosage

Alfuzosin

Side Effects

Feeling dizzy or faint , Headache , Feeling sick (nausea) , Stomach pain , Feeling dizzy, lightheaded, or faint when you stand or sit up quickly (postural hypotension) , Fast Heart beat (tachycardia) and palpitations (pounding in the chest and uneven heartbeat) , Chest Pain , Drowsiness , Diarrhoea , Dry mouth , Rash and itching , Flushes , Water retention (may cause swollen arms or legs). ? Runny nose, itching, sneezing, and stuffy nose , General feeling of being unwell , Problems with your vision.

Drug Interactions

Doxazosin, indoramin, prazosin, terazosin, tamsulosin, or phenoxybenzamine , You are taking medicines for chest pain (angina) , itraconazole , ritonavir , clarithromycin, telithromycin , nefazodone .

Indication

It is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH) ; it is indicated as adjunctive therapy with urethral catheterization for Acute Urinary Retention related to BPH and management following catheter removal.

When not to Use

It is contraindicated in: • Patients with a known hypersensitivity or to any ingredient in the formulation.• Patients with moderate to severe hepatic insufficiency, since alfuzosin blood levels are increased in these patients . • Combination with other alpha1-blockers. • Combination with potent CYP3A4 inhibitors such as ketoconazole, ritonavir and itraconazole, since alfuzosin blood levels and exposure (AUC) are increased.

Xatral-Sr Tablets Precautions

Precaution

Care should be taken when Alfuzosin HCl is administered to patients with symptomatic orthostatic hypotension, in patients who have had a pronounced hypotensive response to another alpha1- blocker or in patients on anti-hypertensive medication or nitrates.

Xatral-Sr Tablets Warnings

Warning 1

Alfuzosin HCl, like other alpha1-blockers (alpha adrenergic antagonists), has been associated with priapism (persistent painful penile erection unrelated to sexual activity). Because this condition can lead to permanent impotence if not properly treated, patients should be advised about the seriousness of the condition and to seek immediate medical attention .

Warning 2

Caution should be taken in patients with histories of tachyarrhythmia or with certain cardiovascular conditions, such as myocardial ischemia. The heart rate increasing effects of alfuzosin are additive to those of other heart rate increasing drugs .

Warning 3

Patients with congenital QTc prolongation, with a known history of acquired QTc prolongation or who are taking drugs known to increase the QTc interval should be evaluated before and during the administration of alfuzosin.

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