Avodart Capsules 0.5Mg

Brand : glaxosmithkline pakistan

Rs. 2,560.20

Rs. 2,695.00

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Avodart Capsules Specification

Requires Prescription (YES/NO)

Yes

Generics

Dutasteride

Used For

Benign Prostatic Hyperplasia

How it works

Dutasteride inhibits the conversion of testosterone to 5a-dihydrotestosterone (DHT). DHT is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to DHT by the enzyme 5a-reductase, which exists as 2 isoforms, type 1 and type 2. The type 2 isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also responsible for testosterone conversion in the skin and liver. Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5a-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human androgen receptor.

Avodart Capsules Usage And Safety

Dosage

Dutasteride

Side Effects

• Skin rash (which can be itchy) • Hives (like a nettle rash) • Swelling of the eyelids, face, lips, arms or legs • Not able to achieve or maintain an erection (impotence), this may continue after you stop taking Dutasteride • decreased sex drive (libido), this may continue after you stop taking Dutasteride • Difficulty with ejaculation, such as a decrease in the amount of semen released during sex, this may continue after you stop taking Dutasteride • Breast enlargement or tenderness (gynecomastia) • Dizziness when taken with tamsulosin • heart failure (heart becomes less efficient at pumping blood around the body • Hair loss (usually from the body) or hair growth.

Drug Interactions

• Verapamil or Diltiazem • ritonavir or indinavir (for HIV) • Itraconazole or ketoconazole • Nefazodone (an antidepressant) • Alpha-blockers (for enlarged prostate or high blood pressure).

Indication

It is used to treat men with an enlarged prostate (benign prostatic hyperplasia) ; A non-cancerous growth of the prostate gland , caused by producing too much of a hormone called dihydrotestosterone.

When not to Use

Do not take • If you are allergic to dutasteride, other 5-alpha reductase inhibitors, soya, peanut or to any of the other ingredients of this medicine • If you have a severe liver disease.

Avodart Capsules Precautions

Precaution

Lower urinary tract symptoms of BPH can be indicative of other urological diseases, including prostate cancer. Patients should be assessed to rule out other urological diseases prior to treatment with Dutasteride. Patients with a large residual urinary volume and/or severely diminished urinary flow may not be good candidates for 5a-reductase inhibitor therapy and should be carefully monitored for obstructive uropathy.

Avodart Capsules Warnings

Warning 1

Dutasteride is absorbed through the skin, therefore, women, children and adolescents must avoid contact with leaking capsules . If contact is made with leaking capsules, the contact area should be washed immediately with soap and water.

Warning 2

Men treated with dutasteride should not donate blood until at least 6 months have passed following their last dose to prevent pregnant women from receiving dutasteride through blood transfusion .

Warning 3

Caution is advised when alpha adrenergic blocking agents including tamsulosin are coadministered with PDE5 inhibitors. Alpha adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. Concomitant use of these two drug classes can potentially cause symptomatic hypotension .