Basoquin Tablets 150Mg (1 Strip = 10 Tablets)

Name: Basoquin Tablets 150Mg (1 Strip = 10 Tablets)
Brand: PFIZER LABORATORIES
Price: 37.30

Brand : pfizer laboratories

Rs. 37.30

Rs. 39.25

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Basoquin Tablets Specification

Requires Prescription (YES/NO)

Yes

Generics

Amodiaquine

Used For

Malaria

How it works

Amodiaquine is a Mannich base 4-aminoquinoline that is similar in structure and mechanism of action to chloroquine. Amodiaquine is converted to its active metabolite desethylamodiaquine and is thought to act by accumulating inside the parasite food vacuole and interfering with haem detoxification. The drug also inhibits the glutathione-dependent destruction of ferriprotoporphyrin IX in the malaria parasite, resulting in the accumulation of this peptide, which is toxic for the parasite. Amodiaquine is effective against some parasite strains that are resistant to chloroquine, although some crossresistance exists .

Basoquin Tablets Usage And Safety

Dosage

Amodiaquine

Side Effects

Abdominal discomfort, nausea, vomiting, headache, dizziness, blurring of vision, mental and physical weakness, and fatigue , itching, cardiovascular abnormalities, dyskinesia, ocular damage, neuromuscular disorders and hearing loss .

Drug Interactions

Increased plasma concentration and elevated liver enzyme activities when given in combination with efavirenz ; Decreased plasma concentration with nevirapine ; Increased risk for neutropenia with zidovudine-containing regimens and trimethoprim plus sulfamethoxazole ; Increased risk for cardiac events with anti-arrhythmic agents ; Visual loss or disturbances with mefloquine ; Recommended to use with caution with inhibitors of CYP2C8 and CYP2A6 ; Amodiaquine may inhibit CYP2D6 and CYP2C9.

Indication

Amodiaquine (AQ) in combination with artesunate is indicated for the treatment of uncomplicated P. falciparum or P. vivax malaria and is considered to be effective against P. ovale, P. knowlesi and P. malariae.

When not to Use

Amodiaquine should not be prescribed in the following conditions: Hypersensitivity to 4-aminoquinoline derivative. Hepatotoxicity; as amodiaquine may concentrate in the liver, the drug should be used with caution in patients with hepatic disease or alcoholism, and in patients receiving hepatotoxic drugs. It is contraindicated in patients with Liver Disease, Neutropenia and Retinopathy .

Basoquin Tablets Precautions

Precaution

Caution should be exercised in patients with G6pD deficiency, nerve disease, any allergy, kidney or liver impairment, during pregnancy and breastfeeding .

Basoquin Tablets Warnings

Warning 1

Avoid long-term use of this medication; otherwise vision loss may occur.

Warning 2

As amodiaquine may concentrate in liver, the drug should be used with caution in patients with hepatic disease and patient receiving hepatotoxic drugs.

Warning 3

Serum ALT levels should be measured in every patient taking the drug who has asthenia and vomiting.

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