Do not stop taking this medication without consulting your doctor. Some conditions may become worse when you suddenly stop this drug. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat. If your doctor decides you should no longer use this drug, he or she may direct you to gradually decrease your dose over 1 to 2 weeks.

There may be an interaction between bisoprolol and any of the following: aldesleukin. aliskiren. alphaagonists (e.g., clonidine, methyldopa) alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin) amifostine. amiodarone. amphetamines (e.g., dextroamphetamine, lisdexamphetamine)