It is used to treat manic episodes associated with bipolar disorder, epilepsy, and migraine headaches.

Nausea, headache, weakness, drowsiness, tremor, abdominal pain, diarrhea, loss of appetite , loss of vision.

It is contraindicated in patients with known hypersensitivity to the drug.

It is contraindicated in patients known to have mitochondrial disorders caused by mutations in mitochondrial DNA polymerase γ (POLG; e.g., Alpers-Huttenlocher Syndrome) and children under two years of age who are suspected of having a POLG-related disorder

Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

Do not use in women of childbearing age unless the drug is essential to the management of the medical condition; all non-pregnant women of childbearing potential should use effective birth control if taking valproate products

Children younger than 2 years are at increased risk for fatal hepatotoxicity, particularly patients on multiple anticonvulsants, as well as those with congenital metabolic disorders, severe seizure disorders accompanied by mental retardation, or organic brain disease

This drug may pose risks to your pregnancy, therefore please do not take this medicine without consulting your doctor first.

Drugs such as doripenem, ertapenem, imipenem/cilastatin, meropenem, sodium oxybate, sodium phenylacetate and vorinostat.