Fansidar Suspension 500+25Mg

Brand : martin dow

Rs. 80.56

Rs. 84.80

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Fansidar Suspension Specification

Requires Prescription (YES/NO)

Yes

Generics

Sulfadoxine , Pyrimethamine

Used For

Malaria

How it works

Sulfadoxine belongs to a group of medicines called sulfonamides. Pyrimethamine belongs to a group of medicines called diaminopyrimidines. Both substances work together in the prevention and treatment of malaria.Sulfadoxine inhibits the activity of dihydropteroate synthase whereas pyrimethamine inhibits dihydrofolate reductase.

Fansidar Suspension Usage And Safety

Dosage

Sulfadoxine , Pyrimethamine

Side Effects

Skin reactions: rash, pruritus, urticaria, photosensitisation and slight hair loss have been observed. These reactions are usually mild and regress spontaneously on withdrawal of the drug. In very rare cases, particularly in hypersensitive patients, severe, possibly life-threatening skin reactions such as erythema multiforme, StevensJohnson syndrome and Lyell's syndrome may occur. Hepatic reactions: there have been isolated reports of a transient rise of liver enzymes as well as hepatitis occurring conjointly with administration of this medicine. Gastrointestinal reactions: feeling of fullness, nausea, infrequently vomiting, diarrhoea, stomatitis. Gastrointestinal disorders appear to be the most commonly reported side effect with the oral formulation. Haematological changes: in infrequent cases, thrombocytopenia, megaloblastic anaemia and leucopenia have been observed, though these usually have been asymptomatic. In isolated cases they take the form of agranulocytosis or purpura. As a rule, all these changes regress after withdrawal of the drug. Other side effects: fatigue, headache, dizziness, fever, and polyneuritis may occasionally occur. Pulmonary infiltrates resembling eosinophilic or allergic alveolitis have been reported in isolated instances.

Drug Interactions

* Chloroquine, a medicine used to treat or prevent malaria * quinine, a medicine used to treat cramps * some cancer medicines * some local anaesthetics * sulfonylureas, a group of medicines used to treat diabetes * methotrexate, a medicine used to treat arthritis, psoriasis and some cancers * some antibiotics, medicines used to treat infection * warfarin, a medicine used to prevent blood clots * phenytoin, a medicine used to treat epilepsy.

Indication

It is used for the prevention and treatment of malaria.

When not to Use

It should not be used in premature or newborn infants in the first two months of life because of the immaturity of their enzyme systems. It is contraindicated in patients who are hypersensitive to sulfonamides, pyrimethamine, or the combination, or any other ingredient in the medicine. Pyrimethamine is also contraindicated in patients with documented megaloblastic anaemia due to folate deficiency. If skin reactions are observed, the drug must be withdrawn immediately, as these may be indicative of a lifethreatening reaction to the drug.

Fansidar Suspension Precautions

Precaution

Pyrimethamine has been reported to cause aplastic anaemia if used between courses of antineoplastic agents. This should be borne in mind when using this medicine.

Fansidar Suspension Warnings

Warning 1

Patients should be advised that sore throat, fever, cough, dyspnoea or purpura may be the first signs of serious side effects. The intake must be stopped immediately at the first signs of skin eruptions, a significant decrease of blood cells, or a bacterial or fungal superinfection.

Warning 2

Excessive exposure to the sun must be strictly avoided.

Warning 3

During prolonged administration of high doses, urinalysis and complete blood cell counts (CBCs), including platelet counts, should be performed periodically. Signs of folic acid deficiency can be prevented by administration of folinic acid.