This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements.

Drowsiness, dizziness, headache, tiredness, blurred vision, dry mouth, and loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

It is contrainticated in patients with known hypersensitivity to the drug.

Before taking diphenoxylate with atropine, tell your doctor or pharmacist if you are allergic to either drug; or to hyoscyamine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (e.g., obstructive jaundice, cirrhosis), loss of too much body water (dehydration), mineral imbalance, a certain type of bowel disease (acute ulcerative colitis), personal or family history of glaucoma (angle-closure type).

Children, particularly those with Down's syndrome, may be more sensitive to the side effects of this drug. Very serious (possibly fatal) effects may occur if too much of this medication is taken by children.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Please consult your doctor when taking this medicine if you are pregnant.

Some products that may interact with this drug are: pramlintide, MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), naltrexone, potassium tablets/capsules.