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      Dvago

      Nicotrim 60Ml Syrup 40Mg/200Mg

      Brand : ray pharma

      Rs. 42.75

      Rs. 45.00

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      Nicotrim 60Ml Specification

      Requires Prescription (YES/NO)

      Yes

      Generics

      Co-triomoxazole

      Used For

      Bacterial Infection

      How it works

      Sulfamethoxazole competitively inhibits the utilisation of para-aminobenzoic acid in the synthesis of dihydrofolate by the bacterial cell resulting in bacteriostasis. Trimethoprim reversibly inhibits bacterial dihydrofolate reductase (DHFR), an enzyme active in the folate metabolic pathway converting dihydrofolate to tetrahydrofolate. Depending on the conditions the effect may be bactericidal. Thus trimethoprim and sulfamethoxazole block two consecutive steps in the biosynthesis of purines and therefore nucleic acids essential to many bacteria. This action produces marked potentiation of activity in vitro between the two agents. Trimethoprim binds to plasmodial DHFR but less tightly than to the bacterial enzyme. Its affinity for mammalian DHFR is some 50,000 times less than for the corresponding bacterial enzyme.

      Nicotrim 60Ml Usage And Safety

      Dosage

      Co-triomoxazole

      Side Effects

      Weakness, fatigue, insomnia, vision troubles, alopecia, epistaxis, local thrombophlebitis at the site of injection, edema , Pseudomembranous enterocolitis, pancreatitis, stomatitis, glossitis, dry mouth, nausea, vomiting, pyrosis, gastric intolerance, gastritis or gastroenteritis, dyspepsia emesis, abdominal pain, constipation, flatulence, diarrhea , Leukopenia, neutropenia, thrombocytopenia, megaloblastic anaemia, aplastic and hemolytic anemia, methemoglobinemia, purpura, agranulocytosis, hypoprothrombinemia, eosinophilia, haemolysis in certain susceptible G-6-PD deficient patients and bone marrow depression ,Arthralgia, rhabdomyolysis and myalgia

      Drug Interactions

      Thiazides , warfarin , Zidovudine , Cyclosporin , Rifampicin , Pyrimethamine , Phenytoin , Digoxin , Methotrexate , Lamivudine , Repaglinide , Folinic acid , Azathioprine .

      Indication

      It is used treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

      When not to Use

      It is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides and in patients with documented megaloblastic anemia due to folate deficiency. It is also contraindicated in pregnant patients at term and in nursing mothers, because sulfonamides pass the placenta and are excreted in the milk and may cause kernicterus. It is contraindicated in pediatric patients less than 2 months of age.

      Nicotrim 60Ml Precautions

      Precaution

      In the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

      Nicotrim 60Ml Warnings

      Warning 1

      It should be given with caution to patients with impaired renal or hepatic function, to those with possible folate deficiency (e.g., the elderly, chronic alcoholics, patients receiving anticonvulsant therapy, patients with malabsorption syndrome, and patients in malnutrition states), and to those with severe allergy or bronchial asthma .

      Warning 2

      Patients should be instructed to maintain an adequate fluid intake in order to prevent crystalluria and stone formation.

      Warning 3

      Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.

      Nicotrim 60Ml Additional Information

      Pregnancy category

      Always consult your physician before using any medicine.

      Storage (YES/NO)

      Store this medicine at room temperature, away from direct light and heat.

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