This is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Metformin and pioglitazone is not for treating type 1 diabetes.

Nausea, vomiting, stomach upset, diarrhea, weakness, sore throat, muscle pain, weight gain, tooth problems or a metallic taste in the mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be signs of lactic acidosis.

It is contraindicated in patients with known hypersensitivity to the drug.

Before taking this medication, tell your doctor or pharmacist if you are allergic to pioglitazoneor metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication may increase the risk of bone fracture (e.g., upper arm, hand, foot, ankle) in female patients. To lower the chance of getting injured, use caution when doing activities such as contact sports.

This medication can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication.

Metformin passes into breast milk in small amounts. It is unknown if pioglitazone passes into breast milk. Consult your doctor before breast-feeding.

Please consult your doctor when taking this medicine if you are pregnant.

Drugs such as Aspirin of low strength,Lipitor,Levemir can interact with this drug.