This medication is used in combination with another drug (mifepristone) to end a pregnancy (abortion).

It can cause severe ongoing stomach discomfort or diarrhea, feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Hypersensitivity to misoprostol, prostaglandins, or prostaglandin analogues

May cause diarrhea, should not be coadministered with other drugs that cause diarrhea (eg, magnesium-containing antacids)

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal disease (e.g., inflammatory bowel disease), risk factors for uterine rupture when this drug is used vaginally (e.g., prior Cesarean delivery, uterine surgery, five or more previous pregnancies).

Safety and efficacy in patients with cardiovascular disease, diabetes, renal impairment, or respiratory disease are not established

Use with caution in women >35 years or heavy smokers (these patients were not included in clinical trials)

This drug is known to cause issues during pregnancy, therefore please do not take this drug if you are pregnant.

Some interactions with this drug include Crofelemer, eluxadoline