Trulicity Injection 1.5Mg/0.5Ml

Brand : eli lilly pakistan pvt ltd.

Rs. 28,296.72

Rs. 29,786.00

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Trulicity Injection Specification

Requires Prescription (YES/NO)

Yes

Generics

Dulaglutide

Used For

Diabetes Management

How it works

It contains dulaglutide, which is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist. The molecule consists of 2 identical disulfide-linked chains, each containing a modified human GLP-1 analogue sequence covalently linked to a modified human immunoglobulin G4 (IgG4) heavy chain fragment (Fc) by a small peptide linker. The GLP-1 analogue portion of dulaglutide is approximately 90% homologous to native human GLP-1 (7-37). It is used to lower blood sugar (glucose) in adults with type 2 diabetes mellitus and can help prevent heart disease.

Trulicity Injection Usage And Safety

Dosage

Dulaglutide

Side Effects

Very common: may affect more than 1 in 10 people - Feeling sick (nausea) – this usually goes away over time - Being sick (vomiting) – this usually goes away over time - Diarrhoea – this usually goes away over time - Stomach (abdominal) pain . Common: may affect up to 1 in 10 people : Low blood sugar (hypoglycaemia) is common when dulaglutide is used alone, or with both metformin and pioglitazone together, or with a sodium-glucose co-transporter 2 inhibitor (SGLT2i) with or without metformin - Feeling less hungry (decreased appetite) - Indigestion - Constipation - Gas (flatulence) - Bloating of the stomach - Reflux or heartburn (also called gastroesophageal reflux disease – GERD) - a disease caused by stomach acid coming up into the tube from your stomach to your mouth - Burping - Feeling tired - Increased heart rate - Slowing of the electrical currents in the heart. Uncommon: may affect up to 1 in 100 people - Injection site reactions (e.g. rash or redness) - Allergic reactions (hypersensitivity) (e.g. swelling, raised itchy skin rash (hives)) - Dehydration, often associated with nausea, vomiting and/or diarrhoea - Gallstones - Inflamed gallbladder

Drug Interactions

Acetaminophen , Atorvastatin , Digoxin , Anti-hypertensives ( lisinopril , metoprolol ) , Warfarin , Oral Contraceptives , Metformin , Sitagliptin .

Indication

It is indicated for the once-weekly treatment of adult patients with type 2 diabetes mellitus to improve glycemic control, in combination with: *Diet and exercise in patients for whom metformin is inappropriate due to contraindication or intolerance. *Metformin, when diet and exercise plus maximal tolerated dose of metformin do not achieve adequate glycemic control. *Metformin and a sulfonylurea, when diet and exercise plus dual therapy with metformin and a sulfonylurea do not achieve adequate glycemic control.

When not to Use

* Patients who are hypersensitive to this drug or to any ingredient in the formulation or component of the container. * In patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2 .* During Pregnancy or in breast-feeding women.

Trulicity Injection Precautions

Precaution

It causes an increase in heart rate . Increases in heart rate may lead to worsening of cardiac conditions in patients with a history of ischemic heart disease or tachyarrhythmias. Caution should be observed in these patient populations.

Trulicity Injection Warnings

Warning 1

It should not be used in patients with type 1 diabetes mellitus or for the treatment of patients with diabetic ketoacidosis.

Warning 2

Patients receiving Dulaglutide in combination with an insulin secretagogue (for example, a sulfonylurea) or insulin may have an increased risk of hypoglycemia. The risk of hypoglycemia may be lowered by a reduction in the dose of the insulin secretagogue or insulin.

Warning 3

Patients treated with dulaglutide should be advised of the potential risk of dehydration and take precautions to avoid fluid depletion.