Zylexx Sr Tablets 75Mg

Brand : araf pharmaceuticals

Rs. 181.30

Rs. 190.80

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Zylexx Sr Specification

Requires Prescription (YES/NO)

Yes

Generics

Bupropion HCl

Used For

Depression

How it works

Bupropion is a selective inhibitor of the neuronal re-uptake of catecholamines (noradrenaline and dopamine) with minimal effect on the re-uptake of indolamines (serotonin) and does not inhibit either monoamine oxidase. The mechanism of action of bupropion as an antidepressant is unknown. However, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms.

Zylexx Sr Usage And Safety

Dosage

Bupropion HCl

Side Effects

Agitation, dry mouth, insomnia, headache/migraine, nausea/vomiting, constipation, and tremor, taste disorders, dizziness, concentration disturbances.

Drug Interactions

Inhibitors/inducers of the CYP2B6 isoenzyme (e.g., orphenadrine, thiotepa, cyclophosphamide, ticlopidine, and clopidogrel) , paroxetine, sertraline, norfluoxetine, and fluvoxamine as well as nelfinavir and efavirenz , antidepressants (SSRIs, many tricyclics), beta-blockers, antiarrhythmics, and antipsychotics , nortriptyline, imipramine, desipramine, antipsychotics e.g., haloperidol, risperidone, thioridazine , beta-blockers (e.g., metoprolol), antiarrhythmics e.g., propafenone, flecainide , MAO Inhibitors , Levodopa and Amantadine , antipsychotics, other antidepressants, theophylline, systemic steroids, Alcohol.

Indication

It is indicated for the treatment of major depressive episodes.

When not to Use

It is contraindicated in patients with hypersensitivity to bupropion or any of the excipients , In patients with a current seizure disorder or any history of seizures , In patients with a known central nervous system tumour.

Zylexx Sr Precautions

Precaution

All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases.

Zylexx Sr Warnings

Warning 1

The recommended dose of modified release bupropion should not be exceeded, since bupropion is associated with a dose-related risk of seizure.

Warning 2

It should be discontinued promptly if patients experience hypersensitivity reactions during treatment.

Warning 3

There is limited clinical experience of the use of bupropion to treat depression in patients with cardiovascular disease. Care should be exercised if it is used in these patients. However, bupropion was generally well tolerated in studies for smoking cessation in patients with ischaemic cardiovascular disease.